SpywareBlaster does not need to be running to provide protection.

After you enable protection for any / all items, you can exit the program and you will still be protected (SpywareBlaster does not need to be running in the background).

You do not have to start up SpywareBlaster each time you start your computer either - your protection remains in place until you disable it (whether SpywareBlaster is running or not).

We do recommend that you run SpywareBlaster at least once a week to download database updates and enable protection for them (or consider AutoUpdate).